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Membrane Organization and Dynamics


Membrane Organization and Dynamics


Springer Series in Biophysics, Band 20

von: Amitabha Chattopadhyay

166,59 €

Verlag: Springer
Format: PDF
Veröffentl.: 06.12.2017
ISBN/EAN: 9783319666013
Sprache: englisch

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Beschreibungen

This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales. The implication of such dynamic information on membrane function in health and disease is a topic of contemporary interest. The chapters cover various aspects of membrane lipid and protein dynamics, explored using a battery of experimental and theoretical approaches. The synthesis of information and knowledge gained by utilizing multiple approaches will provide the reader with a comprehensive understanding of the underlying membrane dynamics and function, which will help to develop robust dynamic models for the understanding of membrane function in healthy and diseased states.   In the last few years, crystal structures of an impressive number of membrane proteins have been reported, thanks to tremendous advances in membrane protein crystallization techniques. Some of these recently solved structures belong to the G protein-coupled receptor (GPCR) family, which are particularly difficult to crystallize due to their intrinsic flexibility. Nonetheless, these static structures do not provide the necessary information to understand the function of membrane proteins in the complex membrane milieu. This volume will address the dynamic nature of membrane proteins within the membrane and will provide the reader with an up-to date overview of the theory and practical approaches that can be used.   This volume will be invaluable to researchers working in a wide range of scientific areas, from biochemistry and molecular biology to biophysics and protein science. Students of these fields will also find this volume very useful. This book will also be of great use to those who are interested in the dynamic nature of biological processes. 
Table of Contents1 Biomembrane Organization and Dynamics: What is So Unique ?Amitabha Chattopadhyay  Centre for Cellular and Molecular Biology, Hyderabad, India E-mail: amit@ccmb.res.in  2 G-protein Coupled Receptors Signaling:  Membrane Diffusion and Organization matterLaurence Salomé   Institute of Pharmacology and Structural Biology, CNRS, France E-mail: laurence.salome@ipbs.fr3 Nanoparticle Probes of Single Molecule Rotation (or Motion) on Cell SurfacesGeorge Barisas  Colorado State University Fort Collins, CO, U.S.A. E-mail:george.barisas@colostate.edu 4 Organization of Membrane Proteins and Peptides using Multidimensional MicroscopyAndrew Clayton Swinburne University of Technology Centre for Micro-Photonics Victoria, Australia E-mail: aclayton@swin.edu.au5 Probing Membrane Domain Heterogeneity with k-space Image Correlation SpectroscopyPaul Wiseman Department of Chemistry McGill University Montreal, Quebec, Canada E-mail: paul.wiseman@mcgill.ca6 Role of Membrane Domains for GPCR FunctionsEvgeni Ponimaskin Cellular Neurophysiology Hannover Medical School Hannover, Germany E-mail: Ponimaskin.Evgeni@mh-hannover.de7 Investigating the Dynamics and Organization of Membrane Proteins and Lipids using Imaging  Fluorescence Correlation Spectroscopy (Imaging FCS)Thorsten Wohland  NUS Centre for Bio-Imaging Sciences, National University of Singapore, Singapore E-mail: twohland@nus.edu.sg8 Combining MD Simulation and NMR Spectroscopy to Investigate the Structure and Dynamics of Membrane Constituents and Membrane Associated Proteins9 Quantifying Membrane Protein Oligomerization by Single Molecule MethodsGerhard J. Schuetz Institute of Applied Physics Vienna University of Technology Wien, Austria E-mail: schuetz@iap.tuwien.ac.at10 Interaction of Amphiphilic Molecules with Lipid Bilayers: Kinetics of Insertion, Desorption and TranslocationLuís M. S. Loura  Centro de Química de Coimbra  University of Coimbra, Coimbra, Portugal E-mail: lloura@ff.uc.pt 11 Organization and Dynamics of Archaeal Tetraether Lipid MembranesParkson Lee-Gau Chong  Department of Medical Genetics & Molecular Biochemistry  Temple University School of Medicine Philadelphia, Pennsylvania, U.S.A. E-mail: pchong02@temple.edu12 Dynamics of Ion Channels in MembranesM. K. Mathew  Laboratory of Membrane Biophysics National Centre for Biological Sciences, TIFR Bangalore, India E-mail: mathew@ncbs.res.in13 Nanoscale Dynamics of Neurotransmitter Receptors and Lipid PlatformsFrancisco J. Barrantes  Laboratory of Molecular Neurobiology Institute of Biomedical Research (BIOMED)  Pontifical Catholic University of Argentina  Ciudad Autónoma de Buenos Aires Argentina E-mail: rtfjb1@yahoo.com ; rtfjb1@criba.edu.ar14 Role of Omega-3 Fatty Acids in Membrane Cholesterol Domain Formation under Disease ConditionsR. Preston Mason  Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston, MA, U.S.A.E-mail: rpmason@elucidaresearch.com15 Computer Simulation of Membrane ProteinsCarmen Domene, Department Chemistry, King's College, London, UKE-mail: carmen.domene@kcl.ac.uk16 GPCR Organization and Oligomerization: Role of Membrane LipidsAmitabha Chattopadhyay (Co-author: Durba Sengupta) Centre for Cellular and Molecular Biology, Hyderabad, India E-mail: amit@ccmb.res.in 
Describes the dynamics of membrane OrganizationHighlights the importance of membrane dynamics in health and diseaseIllustrates the variety of techniques that can be used for membrane dynamics studies
Describes the dynamics of membrane OrganizationHighlights the importance of membrane dynamics in health and diseaseIllustrates the variety of techniques that can be used for membrane dynamics studies

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